Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

Differentiation of Murine Myeloid-Derived Suppressor Cells

Myeloid-derived suppressor cells (MDSCs) are frequently defined as a heterogeneous population of immature cells belonging to the myeloid lineage which possess strong immunosuppressive activities. These cells ultimately derive from myeloid progenitors mainly present in the bone marrow that undergo a dysregulated differentiation pathway, ending up with the systemic mobilization of MDSCs of “monoc...

Myeloid-Derived Suppressor Cell Function Inhibition of Tumor-Induced

Molecular mechanisms regulating myogenic determination and differentiation.

The myogenic regulatory factors are necessary for the determination and terminal differentiation of skeletal muscle. Gene targeting experiments have demonstrated that MyoD and Myf5 are important for myogenic determination whereas myogenin and MRF4 are important for terminal differentiation and lineage maintenance. During development, all trunk skeletal muscle is derived from the somite. Two spa...

Estrogens drive myeloid-derived suppressor cell accumulation

The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury

The mammalian target of rapamycin (mTOR) signal controls innate and adaptive immune response in multiple immunoregulatory contexts. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells of potent immunosuppressive capacity. In this study, we aimed to investigate the role of MDSCs in the protection of acute kidney injury (AKI) and the regulation of mTOR signal ...